Main Outcomes and Measures Dual allergy to cefazolin and a natural penicillin. Bayesian meta-analysis was used to estimate the frequency of allergic reactions. A total of 3228 studies were identified and 2911 were screened for inclusion.ĭata Extraction and Synthesis Data were independently extracted by 2 authors. Study Selection In this systematic review and meta-analysis, a search of MEDLINE/PubMed, Web of Science, and Embase was performed for articles published from database inception to July 31, 2020, for studies that included patients who had index allergies to a natural penicillin and were tested for tolerability to cefazolin or that included patients who had index allergies to cefazolin and were tested for tolerability to a natural penicillin.
Objective To examine the incidence of dual allergy to cefazolin and natural penicillins.ĭata Sources MEDLINE/PubMed, Web of Science, and Embase were searched without language restrictions for relevant articles published from database inception until July 31, 2020. Surgical patients labeled as having penicillin allergy are less likely to prophylactically receive cefazolin and more likely to receive clindamycin or vancomycin, which results in higher rates of surgical site infections. Importance Cefazolin is the preoperative antibiotic of choice because it is safer and more efficacious than second-line alternatives. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.
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